Publications

About GPIHBP1, LPL, and Plasma Triglyceride Metabolism

  1. Miyashita K, Lutz J, Hudgins LC, Toib D, Ashraf AP, Song W, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP. (2020) Chylomicronemia from GPIHBP1 autoantibodies. J. Lipid Res. 61(11): 1365–1376. doi: 10.1194/jlr.R120001116.
  2. Luz J, Beigneux A, Asamoto DK, He C, Song W, Allan CM, Morales JE, Tu Y, Kwok A, Cottle T, Meiyappan M, Fong LG, Kim J, Ploug M, Young SG, Birrane G. (2020) The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase. J. Lipid Res. 61(10): 1347–1359. doi: 10.1194/jlr.RA120000993.
  3. Lutz J, Dunaj-Kazmierowska M, Arcan S, Kassner U, Miyashita K, Murakami M, Ploug M, Fong LG, Young SG, Nakajima K, Beigneux AP. (2020) Chylomicronemia from GPIHBP1 autoantibodies successfully treated with rituximab: a case report. Ann. Intern. Med. 173(9): 764–765. doi: 10.7326/L20-0327. 
  4. Ashraf AP, Miyashita K, Nakajima K, Murakami M, Hegele RA, Ploug M, Fong LG, Young SG, Beigneux AP. (2020) Intermittent chylomicronemia caused by intermittent GPIHBP1 autoantibodies. J Clin Lipidol. doi: 10.1016/j.jacl.2020.01.012. Epub 2020 Jan 31.
  5. Young SG, Fong LG, Beigneux AP, Allan CM, He C, Jiang H, Nakajima K, Meiyappan M, Birrane G Ploug M. (2019) GPIHBP1 and lipoprotein lipase, partners in plasma triglyceride metabolism. Cell Metab. 30: 51?65.
  6. Beigneux, AP, Allan CM, Sandoval NP, Cho GW, Heizer PJ, Jung RS, Stanhope KL, Havel PJ, Birrane G, Meiyappan M, Gill JE, Murakami M, Miyashita K, Nakajima K, Ploug M, Fong SG, Young SG. (2019) Lipoprotein lipase is active as a monomer. Proc. Natl. Acad. Sci. USA Mar 8. pii: 201900983. doi: 10.1073/pnas.1900983116. [Epub ahead of print]
  7. Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Morales JE, Sajti E, Troutman TD, Saunders TL, Cusanovich DA, Beigneux AP, Romanoski CE, Fong LG, Young SG. (2018) An upstream enhancer regulates GPIHBP1 expression in a tissue-specific manner. J Lipid Res. 2018 Dec 31. pii: jlr.M091322. doi: 10.1194/jlr.M091322. [Epub ahead of print]
  8. Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M. (2018) Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis. Proc Natl Acad Sci U S A. 2018 Dec 17. pii: 201817984. doi: 10.1073/pnas.1817984116.
  9. Eguchi J, Miyashita K, Fukamachi I, Nakajima K, Murakami M, Kawahara Y, Yamashita T, Ohta Y, Abe K, Nakatsuka A, Mino M, Takase S, Okazaki H, Hegele RA, Ploug M, Hu X, Wada J, Young SG, Beigneux AP. (2018) GPIHBP1 autoantibody syndrome during interferon B1A treatment. J Clin Lipidol. 2018 Oct 24. pii: S1933-2874(18)30424-0. doi: 10.1016/j.jacl.2018.10.004. [Epub ahead of print]
  10. Miyashita K, Fukamachi I, Machida T, Nakajima K, Young SG, Murakami M, Beigneux A, Nakajima K. (2018) An ELISA for quantifying GPIHBP1 autoantibodies and making a diagnosis of the GPIHBP1 autoantibody syndrome. Clin Chim Acta. 2018 Dec;487:174-178. doi: 10.1016/j.cca.2018.09.039. Epub 2018 Oct 1
  11. Kristensen KK, Midtgaard SR, Mysling S, Kovrov O, Hansen LB, Skar-Ginsling N, Beigneux AP, Kragelund BK, Olivecrona G, Young SG, Jørgensen TJD, Fong LG, Ploug M.  (2018) Disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase. Proc. Natl. Acad. Sci USA 115: E6020-E6029. PMC6042107.
  12. Miyashita K, Fukamachi I, Nagao M, Ishida T, Kobayashi J, Machida T, Nakajima K, Murakami M, Ploug M, Beigneux, AP, Young SG, and Nakajima K. (2018) An enzyme-linked immunosorbent assay for measuring GPIHBP1 levels in human plasma or serum. J. Clin. Lipidol. 12:203?210. PMC5963937
  13. Hu X, Dallinga-Thie GM, Hovingh GK, Chang SY, Sandoval NP, Dang TLP, Fukamachi I, Miyashita K, Nakajima K, Murakami M, Fong LG, Ploug M, Yung SG, and Beigneux AP. (2017) GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia. J. Clin. Lipidology 11: 964?971 PMC 5568906
  14. Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida MT, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, and SG Young. (2017) Autoantibodies against GPIHBP1 as a cause of hypertriglyceridemia. New Engl. J. Med. 376:1647?1658. doi: 10.1056/NEJMoa1611930. Epub 2017 Apr 5. PMC5555413
  15. Hu, X., M. W. Sleeman, K. Miyashita, M. F. Linton, C. M. Allan, C. He, M. Larsson, Y. Tu, N. P. Sandoval, R. S. Jung, A. Mapar, T. Machida, M. Murakami, K. Nakajima, M. Ploug, L. G. Fong, S. G. Young, and A. P. Beigneux. 2017. Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL. J Lipid Res 58:208?215. PMC5234723
  16. Allan CM, Larsson M, Hu X, He C, Jung RS, Mapar A, Voss C, Miyashita K, Machida T, Murakami M, Nakajima K, Bensadoun A, Ploug M, Fong LG, Young SG, Beigneux AP (2016). A lipoprotein lipase (LPL)-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1. J Lipid Res. 57:1889?1898. PMC5036369
  17. Dijk W, Beigneux AP, Fong LG, Larsson M, Young SG, and Kersten S. Angiopoietin-like 4 (ANGPTL4) promotes intracellular degradation of lipoprotein lipase in adipocytes. (2016) J Lipid Res. 57:1670?1683. PMC5003152
  18. Adeyo O, Oberer M, Ploug M, Fong LG, Young SG, Beigneux AP. (2015) Heterogeneity in the properties of mutant secreted lymphocyte antigen 6/urokinase receptor-related protein 1 (SLURP1) in Mal de Meleda. Br J Dermatol. 2015 Oct;173(4): 1066-9. doi: 10.1111/bjd.13868. Epub 2015 Aug 19. PMC4624039
  19. Beigneux AP, Fong LG, Bensadoun A, Davies BS, Oberer M, Gårdsvoll H, Ploug M, Young SG (2015) GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding. Circ. Res. 116:624?632. PMC4329087
  20. Plengpanich W, Young SG, Khovidhunkit W, Bensadoun A, Karnman H, Ploug M, Gardsvoll H, Leung CS, Adeyo O, Larsson M, Muanpetch S, Charoen S, Fong LG, Niramitmahapanya S, Beigneux AP (2014) Multimerization of GPIHBP1 and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1?s Ly6 domain. J. Biol. Chem. 289:19491?19499. PMC4094059
  21. Bensadoun A, Mottler CD, Pelletier C, Wu D, Seo JJ, Leung CS, Adeyo O, Goulbourne CN, Gin P, Fong LG, Young SG, Beigneux AP. (2014) A new monoclonal antibody, 4-1a, that binds to the amino terminus of human lipoprotein lipase. Biochm Biophys Acta. 2014 Jul;1841(7):970-6. doi: 10.1016/j.bbalip.2014.04.008. Epub 2014 Mar 28. PMC4222086
  22. Gin P, Goulbourne CN, Adeyo O, Beigneux AP, Davies BSJ, Tat S, Voss CV, Bensadoun A, Fong LG, Young SG (2012) Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1. Human Mol. Genetics 21:2961-2972. PMC3373243
  23. Voss CV, Davies B, Shelly Tat, Gin P, Fong LG, Pelletier C, Mottler C, Bensadoun A, Beigneux AP, Young SG. (2011) Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1. Proc. Natl. Acad. Sci. USA, 108:7980?7984. PMC3093490
  24. Beigneux AP, Davies BSJ, Tat S, Chen J, Gin P, Voss CV, Weinstein MM, Bensadoun A, Pullinger C, Fong LG, Young SG. (2011) Assessing the role of glycosylphosphatidylinositol-anchored high density lipoprotein?binding protein 1?s three-finger domain in binding lipoprotein lipase. J. Biol. Chem. 286:19735?19743. PMC3103352
  25. Gin P, Beigneux AP, Voss C, Davies BSJ, Beckstead JA, Ryan RO, Bensadoun A, Fong LG, Young SG. (2010) Binding preferences for GPIHBP1, a GPI-anchored protein of capillary endothelial cells. Arterioscler Thromb Vasc Biol. 30:2106?2113. PMC3004026
  26. Davies BS, Beigneux AP, Barnes RH II, Tu Y, Gin P, Weinstein MM, Nobumori C, Nyrén R, Goldberg I, Olivecrona G, Bensadoun A, Young SG, Fong LG. (2010) GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. Cell Metabolism 12:42?52. PMC2913606
  27. Franssen R, Young SG, Peelman F, Hertecant J, Sierts JA, Schimmel AW, Bensadoun A, Kastelein JJ, Fong LG, Dallinga-Thie GM, Beigneux AP. (2010) Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects. Circulation: Cardiovasc. Gen. 3:169?178. PMC2858258
  28. Olivecrona G, Ehrenborg E, Semb H, Makoveichuk E, Lindberg A, Hayden MR, Gin P, Davies BS, Weinstein MM, Fong LG, Beigneux AP, Young SG, Olivecrona T, Hernell O. (2009) Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia. J. Lipid Res. 51:1535?1545. PMC3035517
  29. Beigneux AP, Gin P, Davies BS, Weinstein MM, Bensadoun A, Fong LG, Young SG. (2009) Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase. J. Biol. Chem. 284:30240?30247. PMC2781579
  30. Beigneux AP, Franssen R, Bensadoun A, Gin P, Melford K, Peter J, Walzem RL, Weinstein MM, Davies BS, Kuivenhoven JA, Kastelein JJ, Fong LG, Dallinga-Thie GM, Young SG. (2009) Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase. Arterioscler. Thromb. Vasc. Biol. 29:956?962. PMC2811263
  31. Davies BS, Waki H, Beigneux AP, Farber E, Weinstein MM, Wilpitz DC, Tai L, Evans RM, Fong LG, Tontonoz P, Young SG. (2008) The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by PPAR?. Molec. Endocrin. 22:2496?2504. PMC2582544
  32. Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG. (2007) Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons. Cell Metabolism 5:279?291. PMC191391